| Saturday, August 14, 2010 | |||||
| Time | Home | Away | VENUE | ||
| Aug 14 11:45 GMT | Tottenham Hotspur | vs | Manchester City | White Hart Lane  | |
| Aug 14 14:00 GMT | Aston Villa | vs | West Ham United | Villa Park | |
| Aug 14 14:00 GMT | Blackburn Rovers | vs | Everton | Ewood Park | |
| Aug 14 14:00 GMT | Bolton Wanderers | vs | Fulham | Reebok Stadium | |
| Aug 14 14:00 GMT | Sunderland | vs | Birmingham | Stadium of Light | |
| Aug 14 14:00 GMT | Wigan Athletic | vs | Blackpool | The DW Stadium | |
| Aug 14 14:00 GMT | Wolverhampton Wanderers | vs | Stoke City | Molineux Stadium | |
| Aug 14 16:30 GMT | Chelsea | vs | West Bromwich Albion | Stamford Bridge | |
| Sunday, August 15, 2010 | |||||
| Time | Home | Away | VENUE | ||
| Aug 15 15:00 GMT | Liverpool | vs | Arsenal | Anfield | |
| Monday, August 16, 2010 | |||||
| Time | Home | Away | VENUE | ||
| Aug 16 19:00 GMT | Manchester United | vs | Newcastle United | Old Trafford | |
| Saturday, August 21, 2010 | |||||
| Time | Home | Away | VENUE | ||
| Aug 21 14:00 GMT | Arsenal | vs | Blackpool | Emirates Stadium | |
| Aug 21 14:00 GMT | Birmingham | vs | Blackburn Rovers | St Andrews Stadium | |
| Aug 21 14:00 GMT | Everton | vs | Wolverhampton Wanderers | Goodison Park | |
| Aug 21 14:00 GMT | Stoke City | vs | Tottenham Hotspur | Britannia Stadium | |
| Aug 21 14:00 GMT | West Bromwich Albion | vs | Sunderland | The Hawthorns | |
| Aug 21 14:00 GMT | West Ham United | vs | Bolton Wanderers | Upton Park | |
| Aug 21 16:15 GMT | Wigan Athletic | vs | Chelsea | The DW Stadium | |
| Sunday, August 22, 2010 | |||||
| Time | Home | Away | VENUE | ||
| Aug 22 12:30 GMT | Newcastle United | vs | Aston Villa | St James' Park | |
| Aug 22 15:00 GMT | Fulham | vs | Manchester United | Craven Cottage | |
| Monday, August 23, 2010 | |||||
| Time | Home | Away | VENUE | ||
| Aug 23 19:00 GMT | Manchester City | vs | Liverpool | City of Manchester Stadium | |
| Saturday, August 28, 2010 | |||||
| Time | Home | Away | VENUE | ||
| Aug 28 11:45 GMT | Blackburn Rovers | vs | Arsenal | Ewood Park | |
| Aug 28 14:00 GMT | Blackpool | vs | Fulham | Bloomfield Road | |
| Aug 28 14:00 GMT | Chelsea | vs | Stoke City | Stamford Bridge | |
| Aug 28 14:00 GMT | Tottenham Hotspur | vs | Wigan Athletic | White Hart Lane | |
| Aug 28 14:00 GMT | Wolverhampton Wanderers | vs | Newcastle United | Molineux Stadium | |
| Aug 28 16:30 GMT | Manchester United | vs | West Ham United | Old Trafford | |
| Sunday, August 29, 2010 | |||||
| Time | Home | Away | VENUE | ||
| Aug 29 12:30 GMT | Bolton Wanderers | vs | Birmingham | Reebok Stadium | |
| Aug 29 14:00 GMT | Liverpool | vs | West Bromwich Albion | Anfield | |
| Aug 29 14:00 GMT | Sunderland | vs | Manchester City | Stadium of Light | |
| Aug 29 15:00 GMT | Aston Villa | vs | Everton | Villa Park | |
